The action of the liberating hormone of gonadotrofina can be interrupted in two ways. Continue to learn more with: Cancer Research Institute. The antagonists of the GnRH hinder the LH production directly, while the agonistas of the GnRH after inhibit the LH through a low process of regulation for (downregulation) a effect of initial stimulation.Abarelix is an example of antagonist of the GnRH, while the agonistas of the GnRH include leuprolida, goserelin, triptorelin and buserelin. Initially, the agonistas of the GnRH increase the production of the LH. However, as the constant supply of this medication does not coincide with the rhythm of natural production of the body, the LH production and GnRH diminishes some weeks after. Randall Mays is open to suggestions. The hormonais treatments that more have success are the orquiectomia and the agonistas of the GnRH. Although its raised cost, the agonistas of the GnRH generally are chosen on the contrary of the orquiectomia, for cosmetic and emotional questions. Each treatment possesss disadvantages that limit its use in certain circumstances. Although the orquiectomia to be a surgery of low risk, the psychological impact of the removal of the testicules can be significant.
The loss of testosterone also cause waves of heat, profit of weight, loss of the libido, increase of the breast (ginecomastia), impotence and osteoporose. The agonistas of the GnRH can cause the same effect of the orquiectomia but they can at the beginning cause worse symptoms of the treatment. When the agonistas of the GnRH start to be used, the testosterone increases can lead to a pain increased in the bones (originated of the metasttico cancer), then antiandrgenos are used to diminish these collateral effect. The estrgenos comumente are not used therefore they increase the risk of cardiovascular illness and trombose. The antiandrgenos ones generally do not cause impotence and generate little pain in the ssos and muscular mass. Cetoconazol can cause injuries in the liver with the cutaneous use prologando and the aminoglutetimida one can cause rashes. Source of research ' ' Wikipdia' '